Factors which initiate or influence edema in the isolated dog's heart.

EDEMA of the heart muscle appears to be a nonspecific response to various types of cardiac injury, as pointed out in several publications recently reviewed. *• The evolution of myocardial edema has not been studied in controlled experiments, although the increased water content or the edematous appearance of certain postmortem heart-muscle specimens has elicited comment and speculation, widely scattered through the literature. The present report describes the production and evolution of myocardial edema in isolated dog hearts.